Research Overview | NanoCytomics

Colon Cancer

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Lung Cancer

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Publications and Presentations

Over the past six years the NanoCytomics team ighas had 29 research papers published in peer-reviewed journals. These data have informed our goal to help millions of people survive cancer, develop our proprietary partial wave spectroscopic (PWS) microscopy, and sharpen our focus on potential clinical applications.

We are committed to continuing to contribute to the medical community’s understanding of and appreciation for the science and potential clinical benefits of our technology platform.

Selected research:

Clinical

R. K. Wali, T. A. Hensing, D. W. Ray, M. Dela Cruz, A. Tiwari, A. Radosevich, L. Jepeal, H.C. Fernando, V. Litle, M. Charlot, N. Momi, V. Backman, H.K. Roy, “Buccal microRNA dysregulation in lung field carcinogenesis: gender specific implications”, International Journal of Oncology (2014).
V. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. Goldberg, J. Chennat, L. Karl, M. Ferguson, I. Waxman, H. Roy, V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening”, Endoscopy, 45, 983-988, (2013).
H.K. Roy, D.P. Damania, M. DelaCruz, D.P. Kunte, H. Subramanian, S.E.Crawford, A.K. Tiwari, R.K. Wali, V. Backman, “Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening”, Cancer Prevention Research, 6, 1111-1119 (2013).
V. Backman, H.K. Roy, “Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification”, Journal of Cancer, 4(3), 251-261 (2013) (invited paper).
D. Damania, H.K. Roy, D. Kunte, J.A. Hurteau, H. Subramanian, L. Cherkezyan, M. Shah, N. Krosnjar, V. Backman, “Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cancer cells” International Journal of Cancer, 133(5), 1143-1152 (2013).
H.K. Roy, V. Backman, “Spectroscopic applications in gastrointestinal endoscopy”, Clinical Gastroenterology and Hepatology, 10(12), 1335-1341 (2012).
D. Damania, H.K. Roy, H. Subramanian, M.J. Goldberg, D.S. Weinberg, J. Muldoon, L. Cherkezyan, Y. Zhu, L.K. Bianchi, D. Shah, P. Pradhan, M. Borkar, H. Lynch, V. Backman,“Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization”, Cancer Research, 72(11), 2720-2727 (2012).
D.P.Kunte, M. De LaCruz, R.K. Wali, Y. Stypula, A.K. Tiwari, J. Brasky, T. Gibson, P. Subramaniyan, A. Menon, V. Backman, H.K. Roy, “Dysregulation of MicroRNAs in Early Colon Carcinogenesis: Implications for Screening”, PLoS One, (9)7, e45591(2012).
V. Backman, H.K. Roy, “Light-scattering Technologies for Field Carcinogenesis Detection: A Modality for Endoscopic Pre-screening”, Gastroenterology, 140(1), 35-41 (2011). PMC3319699
H.K. Roy, M.J. Goldberg, S. Bajaj, V. Backman, “Colonoscopic Optical Biopsy: Bridging Technological Advances to Clinical Practice”, Gastroenterology, 140(7),1863–1880 (2011) (invited editorial, cover article). PMC3557924
H.K. Roy, T. Hensing, V. Backman, “Nanocytology for field carcinogenesis detection: novel paradigm for lung cancer risk stratification”, Future Oncology, 7(11), 1-3 (2011) (editorial).
H.K. Roy, H. Subramanian, D. Damania, T. Hensing, D. Ray, A. Bogojevic, P. Pradhan, J. Rogers, N. Hasabou, I. Capoglu, V. Backman, “Optical Detection of Buccal Epithelial Nano-Architectural Alterations in Patients Harboring Lung Cancer: Implications for Screening”, Cancer Research, 70(20), 7748-7754 (2010).
H. Subramanian, H.K. Roy, P. Pradhan, M.J. Goldberg, R.E. Brand, C. Sturgis, T. Hensing, D. Ray, J.-S. Chang, J. Mohammed, V. Backman, “Nanoscale Cellular Changes in Field Carcinogenesis Detected by Partial Wave Spectroscopy”, Cancer Research, 69(13), 5357-5363 (2009).

Technology

J. Chandler, H. Subramanian, C.D. Maneval, C.A. White, V. Backman, “High-speed spectral nanocytology for early cancer screening”, J. Biomedical Optics, 18(11), 117002 (2013).
I.R. Capoglu, J.D. Rogers, A. Taflove, V. Backman, “The microscope in a computer: Image synthesis from three-dimensional full-vector solutions of Maxwell’s equations at the nanometer scale”, Progress in Optics, 57, 1-91 (2013).
I. Capoglu, A. Taflove, V. Backman, “Computation of tightly-focused laser beams in the FDTD method”, Optics Express, 21(1), 87-101 (2013).
L. Cherkezyan, I. Capoglu, H. Subramanian, J.D. Rogers, D. Damania, A. Taflove, V. Backman, “Interferometric spectroscopy of scattered light can quantify the statistics of subdifractional refractive-index fluctuations”, PRL, 111, 033903 (2013).
L. Cherkezyan, H. Subramanian, V. Stoyneva, J. Rogers, S. Yang, D. Damania, A. Taflove, V. Backman, “Targeted alteration of real and imaginary refractive index of biological cells by histological staining”, Optics Letters, 37(10), 1601-1603 (2012).
I.R. Capoglu, C.A. White, J.D. Rogers, A. Taflove, V. Backman,“Numerical Simulation of Partially-Coherent Broadband Optical Imaging Using the FDTD Method”,Optics Letters, 36(9), 1596-1598 (2011).
N.N. Boustany, S.A. Boppart, V. Backman, “Microscopic Imaging and Spectroscopy with Scattered Light”, Annual Review of Biomedical Engineering, 12, 285–314 (2010).
P. Pradhan, D. Dhwanil, V. Turzhitsky, V. Backman, “Quantification of nanoscale density fluctuations using electron microscopy: Light-localization properties of biological cells”, Applied Physics Lett., 97, 243704, 1-3 (2010).
H. Subramanian, P. Pradhan, Y. Liu, I. Capoglu, J. Rogers, H. Roy, R. Brand, V. Backman, “Partial wave microscopic spectroscopy detects sub-wavelength refractive index fluctuations: an application to cancer diagnosis”, Optics Letters, 34(4), 518-520 (2009).
I.R. Capoglu, A. Taflove, V. Backman, “Generation of an incident focused light pulse in FDTD”, Optics Express, 16(23), 19208-19220 (2008).
H. Subramanian, P. Pradhan, Y. Liu, I. Capoglu, X. Li, J. Rogers, A. Heiftez, D. Kunte, H.K. Roy, A. Taflove, V. Backman, “Optical Methodology for Detecting Histologically Unapparent Nanoscale Consequences of Genetic Alterations in Biological Cells”, PNAS, 105(51), 20124–20129 (2008).

Biology and Biophysics

Y. Stypula-Cyrus, N.N. Mutyal, M.A. Dela Cruz, D.P. Kunte, A.J. Radosevich, R.K.Wali, H.K. Roy, V. Backman, “End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis”, FEBS Letters, 5(3), 829-835 (2014).
H. Matsuda, G.G. Putzel, V. Backman, I. Szleifer, “Macromolecular crowding as a regulator of gene transcription”, Biophysical Journal, 106, 1801-1810 (2014).
L. Cherkezyan, Y. Stypula-Cyrus, H. Subramanian, C. White, M. Dela Cruz, R.K. Wali, M.J. Goldberg, L.K. Bianchi, H.K. Roy, V. Backman, “Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study”, Biomed Central Cancer, 14(189), (2014).
K. Phillips, D. Damania, H. Subramanian, V. Backman, E. Anderson, M.H. Wong, O. McCarty, “Network signatures of nuclear and cytoplasmic density alterations in a model of pre- and post-metastatic colorectal cancer”, J. Biomedical Optics, 19(1), 016016 (2013).
The Physical Sciences-Oncology Centers Network. “A physical sciences network characterization of non-tumorigenic and metastatic cells”. Sci. Rep.3, 1449; DOI:10.1038/srep01449 (2013).
Y. Stypula-Cyrus, D. Damania, D.P. Kunte, M. De La Cruz, H. Subramanian, H.K. Roy, V. Backman, “HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure”, PLoS One, 8(5): e64600 (2013).
J.S. Kim, P. Pradhan, V. Backman, I. Szleifer,“Influence of chromosome density variations on the increase in nuclear disorder strength in carcinogenesis”, Physical Biology, 8(1), 015004, 1-6 (2011).
P. Pradhan, D. Damania, H. Joshi, V. Turzhitsky, H. Subramanian, H.K. Roy, A. Taflove, V. Dravid, V. Backman, “Quantification of Nanoscale Density Fluctuations by Electron Microscopy: probing cellular alterations in early carcinogenesis”, Physical Biology, 8, 026012, 1-9 (2011).
J.S. Kim, V. Backman, I. Szleifer, “Crowding-induced structural alterations of random-loop chromosome model”, Phys. Rev. Lett., 106, 168102, 1-4(2011).
D. Damania, H. Subramanian, A.K. Tiwari, Y. Stypula, D. Kunte, P. Pradhan, H.K. Roy, V. Backman, “Role of cytoskeleton in controlling the disorder strength of cellular nanoscale architecture”, Biophys. J., 99, 989–996 (2010).

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